Human eye exposure to surfactant solutions; in silico determination
نویسندگان
چکیده
For the last three decades we have been dedicated to the development and use of in vitro alternatives to replace and reduce animal testing. the trans-epithelial permeability (teP) assay has been validated internally as an alternative to the Draize rabbit eye test and has been used as part of our safety assessment program for 20 years. Over the last two decades we have compiled a large data set of human ocular testing with end points of eye stinging, bulbar conjunctive redness, palpebral conjunctive redness, and lacrimation. this data set includes ocular testing on approximately 20,000 human eyes with 170,000 end points. I-8-444 Human eye exposure to surfactant solutions; in silico determination R. M. Walters 1, V. R. Walczak 1, A. Robillard 1, M. T. Hamilton 2, M. C. Mack 1, J. Composto 1 and K. M. Martin 1 1Johnson & Johnson, Skillman, USA; 2Wellspring Worldwide, Pittsburgh, USA
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